Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liao, D.I.; Wawrzak, Z.; Calabrese, J.C.; Viitanen, P.V.; Jordan, D.B.
    Crystal structure of riboflavin synthase (2001), Structure, 9, 399-408.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.5.1.9 medicine enzyme is an attractive target for antimicrobial agents, since it is nonexistent in humans Escherichia coli

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.9 structure determination by multiwavelength anomalous diffraction method, modeling Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.9 23000
-
 3 * 23000 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.9 6,7-dimethyl-8-ribityllumazine + 6,7-dimethyl-8-ribityllumazine Escherichia coli
-
 riboflavin + 4-(1'-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.9 Escherichia coli
-
 selenomethionine containing enzyme
-
2.5.1.9 no activity in Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.9 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine active site Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.9 6,7-dimethyl-8-ribityllumazine + 6,7-dimethyl-8-ribityllumazine
-
 Escherichia coli riboflavin + 4-(1'-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.9 trimer 3 * 23000 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.9 additional information no cofactor requirement Escherichia coli