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Literature summary extracted from
- 5-Methylthioribose 1-phosphate: a product of partially purified, rat liver 5'-methylthioadenosine phosphorylase activity (1979), Biochim. Biophys. Acta, 570, 65-73.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.28 | 5'-dimethylthioadenosine | weak | Rattus norvegicus |  |
| 2.4.2.28 | 5'-ethylthioadenosine | - |
Rattus norvegicus | |
| 2.4.2.28 | 5'-methylthiotubercidin | - |
Rattus norvegicus | |
| 2.4.2.28 | 5'-n-Propylthioadenosine | - |
Rattus norvegicus | |
| 2.4.2.28 | adenine | strong | Rattus norvegicus | |
| 2.4.2.28 | S-adenosyl-L-homocysteine | weak | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.28 | 0.00047 | - |
5'-methylthioadenosine | - |
Rattus norvegicus | |
| 2.4.2.28 | 0.2 | - |
phosphate | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.28 | 90000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.28 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.4.2.28 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.4.2.28 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.28 | 0.023 | - |
- |
Rattus norvegicus |
| 2.4.2.28 | 0.0234 | - |
purified enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.28 | 5'-ethylthioadenosine + phosphate | - |
Rattus norvegicus | adenine + 5-ethylthio-D-ribose 1-phosphate | - |
? | |
| 2.4.2.28 | 5'-methylthioadenosine + phosphate | - |
Rattus norvegicus | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? | |
| 2.4.2.28 | 5'-n-propylthioadenosine + phosphate | - |
Rattus norvegicus | adenine + 5-n-propylthio-D-ribose 1-phosphate | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.28 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.28 | 7.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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