EC Number | Application | Comment | Organism |
---|---|---|---|
2.5.1.58 | medicine | - |
Trypanosoma cruzi |
2.5.1.58 | medicine | enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells | Leishmania amazonensis |
2.5.1.58 | medicine | enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells | Trypanosoma cruzi |
2.5.1.58 | medicine | enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells | Leishmania major |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.58 | coexpression of alpha and beta subunits of enzyme by Sf9 cells infected with a recombinant baculovirus | Trypanosoma brucei brucei |
2.5.1.58 | coexpression of alpha and beta subunits of enzyme by Sf9 cells infected with a recombinant baculovirus | Trypanosoma cruzi |
2.5.1.58 | coexpression of alpha and beta subunits of enzyme by Sf9 cells infected with a recombinant baculovirus | Leishmania major |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.58 | Zn2+ | zinc ion is coordinated by three residues in the beta subunit: Asp-297, Cys-299, and H-362 and a water molecule | Trypanosoma brucei brucei | |
2.5.1.58 | Zn2+ | zinc ion is coordinated by three residues in the beta subunit: Asp-297, Cys-299, and H-362 and a water molecule | Trypanosoma cruzi | |
2.5.1.58 | Zn2+ | zinc ion is coordinated by three residues in the beta subunit: Asp-297, Cys-299, and H-362 and a water molecule | Leishmania major |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.58 | Leishmania amazonensis | - |
- |
- |
2.5.1.58 | Leishmania amazonensis LV78 | - |
- |
- |
2.5.1.58 | Leishmania major | Q8WR00 | beta-subunit | - |
2.5.1.58 | Leishmania major | Q8WR01 | alpha-subunit | - |
2.5.1.58 | Trypanosoma brucei brucei | - |
- |
- |
2.5.1.58 | Trypanosoma cruzi | Q8WR02 | Tulahuen, beta-subunit | - |
2.5.1.58 | Trypanosoma cruzi | Q8WR03 | Tulahuen, allelic form II of the alpha-subunit | - |
2.5.1.58 | Trypanosoma cruzi | Q8WR04 | Tulahuen, allelic form I of the alpha-subunit | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.58 | amastigote | - |
Leishmania major | - |
2.5.1.58 | epimastigote | - |
Trypanosoma cruzi | - |
2.5.1.58 | procyclic form | - |
Trypanosoma brucei brucei | - |
2.5.1.58 | promastigote | - |
Leishmania major | - |
2.5.1.58 | trypomastigote | - |
Trypanosoma cruzi | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.58 | farnesyl diphosphate + protein-cysteine | - |
Leishmania amazonensis | diphosphate + S-farnesyl protein | - |
? | |
2.5.1.58 | farnesyl diphosphate + protein-cysteine | enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme | Trypanosoma brucei brucei | diphosphate + S-farnesyl protein | - |
? | |
2.5.1.58 | farnesyl diphosphate + protein-cysteine | enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme | Trypanosoma cruzi | diphosphate + S-farnesyl protein | - |
? | |
2.5.1.58 | farnesyl diphosphate + protein-cysteine | enzyme prefers Gln and Met at the X position but not Ser, Thr or Cys, which are good substrates for mammalian enzyme | Leishmania major | diphosphate + S-farnesyl protein | - |
? | |
2.5.1.58 | farnesyl diphosphate + protein-cysteine | - |
Leishmania amazonensis LV78 | diphosphate + S-farnesyl protein | - |
? |