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Literature summary extracted from

  • Hacham, Y.; Avraham, T.; Amir, R.
    The N-terminal region of Arabidopsis cystathionine gamma-synthase plays an important regulatory role in methionine metabolism (2002), Plant Physiol., 128, 454-462.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.48 overexpression of full-length enzyme and its truncated version that lacks the N-terminal region in transgenic Nicotiana tabacum plants. Transgenic plants expressing both types of enzyme have a significant higher level of Met and S-methyl-Met content in their proteins. Plants expressing full-length enzyme show the same phenotype and developmental pattern as wild-type plants, those expressing the truncated length enzyme show a severely abnormal phenotype. The N-terminal region plays a role in protecting plants from a high level of Met catabolic products such as ethylene Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.48 additional information overexpression of full-length enzyme and its truncated version that lacks the N-terminal region in transgenic Nicotiana tobacum plants. Transgenic plants expressing both types of enzyme have a significant higher level of Met and S-methyl-Met content in their proteins. Plants expressing full-length enzyme show the same phenotype and developmental pattern as wild-type plants, those expressing the truncated length enzyme show a severely abnormal phenotype Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.48 O-succinyl-L-homoserine + L-cysteine Arabidopsis thaliana key enzyme of Met biosynthesis L-cystathionine + succinate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.48 Arabidopsis thaliana
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.48 O-succinyl-L-homoserine + L-cysteine key enzyme of Met biosynthesis Arabidopsis thaliana L-cystathionine + succinate
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 ?