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Literature summary extracted from

  • Daune, G.; Gerhart, F.; Seiler, N.
    5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase (1988), Biochem. J., 253, 481-488.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.13 5-Fluoromethylornithine specific irreversible inhibitor in vivo and in vitro Mus musculus
2.6.1.13 5-Fluoromethylornithine specific irreversible inhibitor in vivo and in vitro Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.13 Mus musculus
-
-
-
2.6.1.13 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.13 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.13 brain
-
 Mus musculus
-
2.6.1.13 brain
-
 Rattus norvegicus
-
2.6.1.13 liver
-
 Mus musculus
-
2.6.1.13 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.13 0.12
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.13 L-ornithine + 2-oxoglutarate
-
 Mus musculus DELTA1-pyrroline-5-carboxylate + L-glutamate
-
 ?
2.6.1.13 L-ornithine + 2-oxoglutarate
-
 Rattus norvegicus DELTA1-pyrroline-5-carboxylate + L-glutamate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.13 0.07
-
 5-Fluoromethylornithine 37°C, pH 8 Rattus norvegicus