EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.60 | hydroxylamine | - |
Rattus norvegicus | |
2.6.1.60 | Isonicotinic hydrazide | - |
Rattus norvegicus | |
2.6.1.60 | KCN | - |
Rattus norvegicus | |
2.6.1.60 | Semicarbazide | strong | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.60 | 0.07 | - |
glyoxylate | cosubstrate L-alanine, 37°C | Rattus norvegicus | |
2.6.1.60 | 0.07 | - |
pyruvate | cosubstrate L-serine, 37°C | Rattus norvegicus | |
2.6.1.60 | 1.5 | - |
pyruvate | cosubstrate L-histidine, 37°C | Rattus norvegicus | |
2.6.1.60 | 2.1 | - |
alanine | cosubstrate L-glyoxylate, 37°C | Rattus norvegicus | |
2.6.1.60 | 2.6 | - |
phenylalanine | cosubstrate pyruvate, 37°C | Rattus norvegicus | |
2.6.1.60 | 2.7 | - |
histidine | cosubstrate pyruvate, 37°C | Rattus norvegicus | |
2.6.1.60 | 5.1 | - |
pyruvate | cosubstrate L-phenylalanine, 37°C | Rattus norvegicus | |
2.6.1.60 | 16 | - |
serine | cosubstrate pyruvate, 37°C | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.6.1.60 | mitochondrion | - |
Mammalia | 5739 | - |
2.6.1.60 | mitochondrion | matrix | Rattus norvegicus | 5739 | - |
2.6.1.60 | additional information | subcellular distribution distribution in different mammalia | Mammalia | - |
- |
2.6.1.60 | peroxisome | - |
Mammalia | 5777 | - |
2.6.1.60 | peroxisome | matrix and soluble | Rattus norvegicus | 5777 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | 40000 | - |
2 * 40000, SDS-PAGE | Rattus norvegicus |
2.6.1.60 | 80000 | - |
gel filtration | Rattus norvegicus |
2.6.1.60 | 80000 | - |
sucrose density gradient centrifugation | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.60 | Mammalia | - |
distribution among mammals | - |
2.6.1.60 | Rattus norvegicus | - |
mitochondrial enzyme inducible by glucagon or cAMP, peroxisomal enzyme inducible by clofibrate | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.60 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.60 | liver | - |
Mammalia | - |
2.6.1.60 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | 12.9 | - |
substrates histidine + pyruvate, 37°C | Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
2.6.1.60 | -20°C, at least 6 weeks | Rattus norvegicus |
2.6.1.60 | 0-5°C, 2 weeks with little or no loss of activity | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.60 | asparagine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 2-oxosuccinamate + glycine | - |
? | |
2.6.1.60 | glutamine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 4-carbamoyl-2-oxobutanoate + glycine | - |
? | |
2.6.1.60 | isoleucine + glyoxylate | poor substrate | Rattus norvegicus | 3-methyl-2-oxopentanoate + glycine | - |
? | |
2.6.1.60 | L-glutamate + glyoxylate | poor substrate | Rattus norvegicus | 2-oxoglutarate + glycine | - |
? | |
2.6.1.60 | L-histidine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | L-kynurenine + glyoxylate | - |
Rattus norvegicus | 3-(2-aminophenyl-)2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.60 | L-leucine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 4-methyl-2-oxopentanoate + glycine | - |
? | |
2.6.1.60 | L-methionine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 4-methylsulfanyl-2-oxobutanoate + glycine | - |
? | |
2.6.1.60 | L-phenylalanine + 2-oxo-4-methylthiobutyrate | - |
Rattus norvegicus | phenylpyruvate + L-methionine | - |
? | |
2.6.1.60 | L-phenylalanine + glyoxylate | - |
Rattus norvegicus | phenylpyruvate + glycine | - |
? | |
2.6.1.60 | L-phenylalanine + hydroxypyruvate | - |
Rattus norvegicus | phenylpyruvate + L-serine | - |
? | |
2.6.1.60 | L-phenylalanine + pyruvate | - |
Rattus norvegicus | phenylpyruvate + L-alanine | - |
? | |
2.6.1.60 | L-serine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 3-hydroxy-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | tyrosine + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | valine + glyoxylate | poor substrate | Rattus norvegicus | 3-methyl-2-oxobutanoate + glycine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.6.1.60 | dimer | 2 * 40000, SDS-PAGE | Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | 37 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.60 | pyridoxal 5'-phosphate | requirement | Rattus norvegicus |