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Literature summary extracted from

  • Braun, L.; Mile, V.; Schaff, Z.; Csala, M.; Kardon, T.; Mandl, J.; Banhegyi, G.
    Induction and peroxisomal appearance of gulonolactone oxidase upon clofibrate treatment in mouse liver (1999), FEBS Lett., 458, 359-362.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.3.8 microsome integral membrane protein in the endoplasmic reticulum Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.8 L-gulono-1,4-lactone + O2 Mus musculus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.8 Mus musculus
-
 mouse treated with clofibrate, a peroxisome proliferator
-
1.1.3.8 no activity in Cavia porcellus
-
 guinea pig
-
1.1.3.8 no activity in Homo sapiens
-
-
-
1.1.3.8 no activity in primates
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.8 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.3.8 additional information
-
 clofibrate-treated mouse enzyme is 8.5fold as active as non-treated mouse enzyme in the microsome and 500fold as active in the peroxisome Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Mus musculus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Mus musculus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.3.8 37
-
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.3.8 flavin covalently bound, flavoenzyme Mus musculus