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Literature summary extracted from

  • Smythe, E.; Williams, D.C.
    Rat liver uroporphyrinogen III synthase has similar properties to the enzyme from Euglena gracilis, including absence of a requirement for a reversibly bound cofactor for activity (1988), Biochem. J., 253, 275-279.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.75 additional information no bound cofactor Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.75 pyridoxal 5'-phosphate
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.2.1.75 additional information
-
 enzyme exists in 2 interconvertible forms, separable on HPLC Rattus norvegicus
4.2.1.75 28000
-
 SDS-PAGE Rattus norvegicus
4.2.1.75 36000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.75 Hydroxymethylbilane Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.75 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.75
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.75 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.75 Hydroxymethylbilane
-
 Rattus norvegicus Uroporphyrinogen III
-
 ?
4.2.1.75 Hydroxymethylbilane
-
 Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.75 monomer SDS-PAGE, gel filtration Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.2.1.75 37
-
 enzyme assay at Rattus norvegicus