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Literature summary extracted from

  • Coote, J.G.; Hassall, H.
    The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by Pseudomonas acidovorans (1969), Biochem. J., 111, 237-239.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.111 (S)-3-(imidazol-5-yl)lactate + NAD(P)+ Delftia acidovorans imidazoyl-lactate formation is favoured 3-(imidazol-5-yl)pyruvate + NAD(P)H
-
 r
2.6.1.38 imidazol-5-yl-pyruvate + L-glutamate Delftia acidovorans
-
 histidine + 2-oxoglutarate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.111 Delftia acidovorans
-
-
-
2.6.1.38 Delftia acidovorans
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.111 7
-
 in crude extracts, cofactor NADH Delftia acidovorans
1.1.1.111 12
-
 in crude extracts, cofactor NADPH Delftia acidovorans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.111 (S)-3-(imidazol-5-yl)lactate + NAD(P)+ imidazoyl-lactate formation is favoured Delftia acidovorans 3-(imidazol-5-yl)pyruvate + NAD(P)H
-
 r
2.6.1.38 imidazol-5-yl-pyruvate + L-glutamate
-
 Delftia acidovorans L-histidine + 2-oxoglutarate
-
 r
2.6.1.38 imidazol-5-yl-pyruvate + L-glutamate
-
 Delftia acidovorans histidine + 2-oxoglutarate
-
 r
2.6.1.38 additional information no activity observed if L-alanine or L-aspartate replaces glutamate, no activity observed if 2-oxoglutarate is replaced by glyoxylate, pyruvate, 2-oxobutyrate or 2-oxoisocaproate Delftia acidovorans ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.111 NAD(P)+ 58% enzyme activity with NADH compared to NADPH Delftia acidovorans