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Literature summary extracted from

  • Keul, V.; Kaeppeli, F.; Ghosh, C.; Krebs, T.; Robinson, J.A.; Retey, J.
    Identification of the prosthetic group of urocanase (1979), J. Biol. Chem., 254, 843-851.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.49 NaBH4
-
 Bos taurus
4.2.1.49 NaBH4
-
 Pseudomonas putida

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.49 Urocanate + H2O Bos taurus
-
 ?
-
 ?
4.2.1.49 Urocanate + H2O Pseudomonas putida
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.49 Bos taurus
-
-
-
4.2.1.49 Pseudomonas putida
-
 formerly Pseudomonas fluorescens ATCC 12633
-
4.2.1.49 Pseudomonas putida
-
 ATCC 11299
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.49
-
 Bos taurus
4.2.1.49
-
 Pseudomonas putida

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.49 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.2.1.49 additional information
-
-
 Bos taurus
4.2.1.49 additional information
-
 NaBH4 treated inactive enzyme is partially photoactivatable Pseudomonas putida
4.2.1.49 1.6
-
-
 Bos taurus
4.2.1.49 1.7
-
-
 Pseudomonas putida

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.49 Urocanate + H2O
-
 Bos taurus 4,5-Dihydro-4-oxo-5-imidazolepropanoate
-
 ?
4.2.1.49 Urocanate + H2O
-
 Pseudomonas putida 4,5-Dihydro-4-oxo-5-imidazolepropanoate
-
 ?
4.2.1.49 Urocanate + H2O
-
 Bos taurus ?
-
 ?
4.2.1.49 Urocanate + H2O
-
 Pseudomonas putida ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.49 dimer
-
 Pseudomonas putida

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.49 NAD+ tightly enzyme-bound Bos taurus
4.2.1.49 NAD+ tightly enzyme-bound Pseudomonas putida