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Literature summary extracted from

  • Cohen, P.; Klee, C.B.; Picton, C.; Shenolikar, S.
    Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin (1980), Ann. N. Y. Acad. Sci., 356, 151-161.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.19 Artificial thin filaments activation, made by mixing actin, tropomyosin and troponin complex Rattus norvegicus
2.7.11.19 Artificial thin filaments activation, made by mixing actin, tropomyosin and troponin complex Oryctolagus cuniculus
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Rattus norvegicus
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Oryctolagus cuniculus
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase at low Mg2+-concentration, 2 phosphorylation sites, one Ser residue on alpha and beta subunit each Rattus norvegicus
2.7.11.19 Catalytic subunit of cAMP-dependent protein kinase at low Mg2+-concentration, 2 phosphorylation sites, one Ser residue on alpha and beta subunit each Oryctolagus cuniculus
2.7.11.19 Catalytic subunit of cGMP-dependent protein kinase not Rattus norvegicus
2.7.11.19 Catalytic subunit of cGMP-dependent protein kinase not Oryctolagus cuniculus
2.7.11.19 additional information no activation by parvalbumin Rattus norvegicus
2.7.11.19 additional information no activation by parvalbumin Oryctolagus cuniculus
2.7.11.19 additional information the nonactivated enzyme is activated either by limited proteolysis Rattus norvegicus
2.7.11.19 additional information the nonactivated enzyme is activated either by limited proteolysis Oryctolagus cuniculus
2.7.11.19 troponin C activation Rattus norvegicus
2.7.11.19 troponin C activation Oryctolagus cuniculus
2.7.11.19 troponin C presumably key event in vivo, coupling glycogenolysis and muscle contraction Rattus norvegicus
2.7.11.19 troponin C presumably key event in vivo, coupling glycogenolysis and muscle contraction Oryctolagus cuniculus
2.7.11.19 troponin C can replace extrinsic calmodulin Rattus norvegicus
2.7.11.19 troponin C can replace extrinsic calmodulin Oryctolagus cuniculus
2.7.11.19 Trypsin proteolytic activation of nonactivated enzyme Rattus norvegicus
2.7.11.19 Trypsin proteolytic activation of nonactivated enzyme Oryctolagus cuniculus
2.7.11.19 Trypsin accompanied by loss of absolute requirement for Ca2+, activates holoenzyme and alphagammadelta subunit complex, not gammadelta complex Rattus norvegicus
2.7.11.19 Trypsin accompanied by loss of absolute requirement for Ca2+, activates holoenzyme and alphagammadelta subunit complex, not gammadelta complex Oryctolagus cuniculus
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits Rattus norvegicus
2.7.11.19 Trypsin strong, by limited proteolysis of alpha and beta subunits Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 Antibodies to delta subunit of phosphorylase kinase
-
 Rattus norvegicus
2.7.11.19 Antibodies to rat testis calmodulin calmodulin or troponin (the latter at high concentrations) reverses Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.19 glycogen particle together with other enzymes of glycogen metabolism linked together on glycogen particles Rattus norvegicus
-
-
2.7.11.19 glycogen particle together with other enzymes of glycogen metabolism linked together on glycogen particles Oryctolagus cuniculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+ delta-subunit confers Ca2+-sensitivity to the phosphorylase kinase reaction Rattus norvegicus
2.7.11.19 Ca2+ delta-subunit confers Ca2+-sensitivity to the phosphorylase kinase reaction Oryctolagus cuniculus
2.7.11.19 Ca2+ requirement (trypsin activation leads to loss of absolute requirement) Rattus norvegicus
2.7.11.19 Ca2+ requirement (trypsin activation leads to loss of absolute requirement) Oryctolagus cuniculus
2.7.11.19 Mg2+ requirement Rattus norvegicus
2.7.11.19 Mg2+ requirement Oryctolagus cuniculus
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Rattus norvegicus
2.7.11.19 Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
2.7.11.19 phosphate requirement, phosphate containing enzyme Rattus norvegicus
2.7.11.19 phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 ATP + glycogen synthase Rattus norvegicus decreases activity of this substrate ?
-
 ?
2.7.11.19 ATP + glycogen synthase Oryctolagus cuniculus decreases activity of this substrate ?
-
 ?
2.7.11.19 ATP + phosphorylase b Rattus norvegicus stimulates glycogenolysis in skeletal muscle ?
-
 ?
2.7.11.19 ATP + phosphorylase b Oryctolagus cuniculus stimulates glycogenolysis in skeletal muscle ?
-
 ?
2.7.11.19 ATP + phosphorylase b Rattus norvegicus regulates conversion of inactive phosphorylase b into active phosphorylase a ?
-
 ?
2.7.11.19 ATP + phosphorylase b Oryctolagus cuniculus regulates conversion of inactive phosphorylase b into active phosphorylase a ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Oryctolagus cuniculus
-
-
-
2.7.11.19 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 skeletal muscle
-
 Rattus norvegicus
-
2.7.11.19 skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + glycogen synthase decreases activity of this substrate Rattus norvegicus ?
-
 ?
2.7.11.19 ATP + glycogen synthase decreases activity of this substrate Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + glycogen synthase
-
 Rattus norvegicus ADP + phosphoglycogen synthase
-
 ?
2.7.11.19 ATP + glycogen synthase
-
 Oryctolagus cuniculus ADP + phosphoglycogen synthase
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Rattus norvegicus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
2.7.11.19 ATP + phosphorylase b stimulates glycogenolysis in skeletal muscle Rattus norvegicus ?
-
 ?
2.7.11.19 ATP + phosphorylase b stimulates glycogenolysis in skeletal muscle Oryctolagus cuniculus ?
-
 ?
2.7.11.19 ATP + phosphorylase b regulates conversion of inactive phosphorylase b into active phosphorylase a Rattus norvegicus ?
-
 ?
2.7.11.19 ATP + phosphorylase b regulates conversion of inactive phosphorylase b into active phosphorylase a Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 More the delta subunit is firmly bound to holoenzyme whereas delta' subunit (i.e. calmodulin) is bound only in the presence of Ca2+ Rattus norvegicus
2.7.11.19 More the delta subunit is firmly bound to holoenzyme whereas delta' subunit (i.e. calmodulin) is bound only in the presence of Ca2+ Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.19 Calmodulin requirement Rattus norvegicus
2.7.11.19 Calmodulin requirement Oryctolagus cuniculus
2.7.11.19 Calmodulin calmodulin containing enzyme i.e. tightly bound delta subunit Rattus norvegicus
2.7.11.19 Calmodulin calmodulin containing enzyme i.e. tightly bound delta subunit Oryctolagus cuniculus
2.7.11.19 Calmodulin in the presence of Ca2+ phosphorylase kinase binds a second molecule calmodulin (i.e. delta' subunit) producing additional activation Rattus norvegicus
2.7.11.19 Calmodulin in the presence of Ca2+ phosphorylase kinase binds a second molecule calmodulin (i.e. delta' subunit) producing additional activation Oryctolagus cuniculus