Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Vitale, G.; Bernardi, L.; Napolitani, G.; Mock, M.; Montecucco, C.
    Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor (2000), Biochem. J., 352, 739-745.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.7.12.2 proteolytic inactivation by anthrax lethal factor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Homo sapiens O14733
-
-
2.7.12.2 Homo sapiens P36507
-
-
2.7.12.2 Homo sapiens P45985
-
-
2.7.12.2 Homo sapiens P52564
-
-
2.7.12.2 Homo sapiens Q02750
-
-
3.4.24.83 Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.83 mitogen-activated protein kinase + H2O substrate: MAPKK4, MAPKK6, MAPKK7, no substrate: MAPKK5 Bacillus anthracis ?
-
 ?
3.4.24.83 additional information cleavage occurs within the N-terminal proline-rich regions of MAPKKs, consensus motifs Bacillus anthracis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 1
-
 Homo sapiens
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 2
-
 Homo sapiens
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 4
-
 Homo sapiens
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 6
-
 Homo sapiens
2.7.12.2 dual specificity mitogen-activated protein kinase kinase 7
-
 Homo sapiens