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Literature summary extracted from

  • Hunter, T.
    Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling (1995), Cell, 80, 225-236.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 additional information one activation process in vertebrates involves activation and translocation to the plasma membrane of Ras, and/or autophosphorylation eukaryota
2.7.11.17 additional information Ras activity can be induced by the nuclear growth factor eukaryota
2.7.11.19 Ca2+/calmodulin the phosphorylase kinase is activated by both cAMP-dependent protein kinase and Ca2+/calmodulin eukaryota
2.7.11.22 cyclin e.g. cyclin A and cyclin B, dependent on, forms a subunit of the enzyme after binding eukaryota
2.7.11.22 additional information regulation by reversible phosphorylation, activation by e.g. CAK, i.e. cyclin-dependent kinase activating kinase, overview eukaryota
2.7.11.24 additional information the enzyme is activated by mitogens, activation is induced by epidermal growth factor tyrosine protein kinase and nucelar growth factor tyrosine protein kinase eukaryota
2.7.12.2 additional information activation is induced by epidermal growth factor tyrosine protein kinase and nucelar growth factor tyrosine protein kinase eukaryota

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 vanadate
-
 eukaryota
2.7.10.2 vanadate
-
 eukaryota
2.7.11.22 additional information regulation by reversible phosphorylation, overview eukaryota

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.1 plasma membrane
-
 eukaryota 5886
-
2.7.10.2 additional information specific localization in different subcellular compartments eukaryota
-
-
2.7.11.22 nucleus CAK eukaryota 5634
-
2.7.11.24 nucleus ERK1, ERK2 eukaryota 5634
-
2.7.12.2 cytoplasm MEK1, MEK2 eukaryota 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.1 Mg2+
-
 eukaryota
2.7.11.17 Ca2+ binding required for activity eukaryota
2.7.11.19 Mg2+
-
 eukaryota
2.7.11.22 Mg2+
-
 eukaryota
2.7.11.24 Mg2+
-
 eukaryota
2.7.11.25 Mg2+
-
 eukaryota
2.7.12.2 Mg2+
-
 eukaryota

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.10.1 additional information eukaryota protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview ?
-
 ?
2.7.10.2 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.10.2 additional information eukaryota protein kinases and protein phosphatases regulate enzyme activities in the cell, overview ?
-
 ?
2.7.11.17 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.11.17 additional information eukaryota protein kinases and protein phosphatases regulate enzyme activities in the cell, overview ?
-
 ?
2.7.11.19 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.11.19 additional information eukaryota protein kinases and protein phosphatases regulate enzyme activities in the cell, overview ?
-
 ?
2.7.11.22 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.11.22 additional information eukaryota regulation mechanisms, overview ?
-
 ?
2.7.11.24 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.11.24 additional information eukaryota enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview ?
-
 ?
2.7.11.25 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.11.25 ATP + MAPKK eukaryota MAPKK activation ADP + phosphorylated MAPKK
-
 ?
2.7.11.25 additional information eukaryota enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview ?
-
 ?
2.7.12.2 ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?
2.7.12.2 ATP + MAPK eukaryota MAPK activation ADP + phosphorylated MAPK
-
 ?
2.7.12.2 additional information eukaryota enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 eukaryota
-
-
-
2.7.10.2 eukaryota
-
-
-
2.7.11.17 eukaryota
-
-
-
2.7.11.19 eukaryota
-
-
-
2.7.11.22 eukaryota
-
-
-
2.7.11.24 eukaryota
-
-
-
2.7.11.25 eukaryota
-
-
-
2.7.12.2 eukaryota
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.1 phosphoprotein the enzyme is activated by autophosphorylation eukaryota
2.7.11.19 phosphoprotein the phosphorylase kinase is activated by cAMP-dependent protein kinase eukaryota
2.7.11.22 phosphoprotein regulation by de-/phosphorylation at Thr residues, overview, phosphorylation has both negative and positive regulating function, overview, CAK phoshorylates and activates cdc2 PK, cdk7 phosphorylates and activates CAK eukaryota
2.7.11.24 phosphoprotein activation by phosphorylation eukaryota
2.7.11.25 phosphoprotein activation by phosphorylation eukaryota
2.7.12.2 phosphoprotein activation by phosphorylation eukaryota

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.10.1 additional information protein kinases and protein phosphatases regulate enzyme activities in the cell, regulation mechanisms, overview eukaryota ?
-
 ?
2.7.10.2 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.10.2 additional information protein kinases and protein phosphatases regulate enzyme activities in the cell, overview eukaryota ?
-
 ?
2.7.10.2 additional information Wee1: substrate specificity eukaryota ?
-
 ?
2.7.11.17 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.11.17 ATP + cAMP-response element-binding protein i.e. CREB, phosphorylation at S133, substrate of CaMKIV and CaMKII eukaryota ADP + phosphorylated cAMP-response element-binding protein
-
 ?
2.7.11.17 ATP + glycogen synthase
-
 eukaryota ADP + phosphorylated glycogen synthase
-
 ?
2.7.11.17 additional information protein kinases and protein phosphatases regulate enzyme activities in the cell, overview eukaryota ?
-
 ?
2.7.11.19 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.11.19 additional information protein kinases and protein phosphatases regulate enzyme activities in the cell, overview eukaryota ?
-
 ?
2.7.11.22 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.11.22 ATP + CAK substrate of cyclin-dependent kinase cdk7 eukaryota ADP + phosphorylated CAK
-
 ?
2.7.11.22 ATP + cdc2 PK substrate of cyclin-dependent kinase activating kinase CAK eukaryota ADP + phosphorylated cdc2 PK
-
 ?
2.7.11.22 additional information regulation mechanisms, overview eukaryota ?
-
 ?
2.7.11.24 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.11.24 additional information enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview eukaryota ?
-
 ?
2.7.11.25 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.11.25 ATP + MAPKK MAPKK activation eukaryota ADP + phosphorylated MAPKK
-
 ?
2.7.11.25 additional information enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview eukaryota ?
-
 ?
2.7.12.2 ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
2.7.12.2 ATP + MAPK MAPK activation eukaryota ADP + phosphorylated MAPK
-
 ?
2.7.12.2 additional information enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview eukaryota ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.22 dimer active for, with cyclin bound as second subunit eukaryota
2.7.11.22 monomer inactive form eukaryota

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 EGF RPTK
-
 eukaryota
2.7.10.1 epidermal growth factor tyrosine protein kinase
-
 eukaryota
2.7.10.1 NGF RPTK
-
 eukaryota
2.7.10.1 nuclear growth factor tyrosine protein kinase
-
 eukaryota
2.7.10.1 platelet-derived growth factor RPTK
-
 eukaryota
2.7.10.1 RPTK
-
 eukaryota
2.7.10.2 Neu oncogenic PTK eukaryota
2.7.10.2 non-receptor PTK
-
 eukaryota
2.7.10.2 v-Fms oncogenic PTK eukaryota
2.7.10.2 v-Src oncogenic PTK eukaryota
2.7.10.2 Wee1
-
 eukaryota
2.7.11.17 Ca2+-CaM-dependent protein kinase II
-
 eukaryota
2.7.11.17 CaMKII
-
 eukaryota
2.7.11.19 phosphorylase kinase
-
 eukaryota
2.7.11.22 CAK
-
 eukaryota
2.7.11.22 cdc2 PK
-
 eukaryota
2.7.11.22 cdk7
-
 eukaryota
2.7.11.22 cyclin-dependent kinase activating kinase
-
 eukaryota
2.7.11.24 ERK1
-
 eukaryota
2.7.11.24 ERK2
-
 eukaryota
2.7.11.24 Fus3
-
 eukaryota
2.7.11.24 Kss1
-
 eukaryota
2.7.11.24 MAP kinase
-
 eukaryota
2.7.11.24 MAPK
-
 eukaryota
2.7.11.25 MAPKKK
-
 eukaryota
2.7.12.2 MAPK kinase
-
 eukaryota
2.7.12.2 MAPKK
-
 eukaryota
2.7.12.2 MEK1
-
 eukaryota
2.7.12.2 MEK2
-
 eukaryota

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.1 ATP
-
 eukaryota
2.7.11.17 ATP
-
 eukaryota
2.7.11.17 Calmodulin binding required for activity eukaryota
2.7.11.19 ATP
-
 eukaryota
2.7.11.22 ATP
-
 eukaryota
2.7.11.24 ATP
-
 eukaryota
2.7.11.25 ATP
-
 eukaryota
2.7.12.2 ATP
-
 eukaryota