Literature summary extracted from

Araujo, L.S.; Lombardo, M.E.; Batlle, A.M.D.C.
Inhibition of porphobilinogenase by porphyrins in Saccharomyces cerevisiae (1994), Int. J. Biochem., 26, 1377-1381.

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.5.1.61	0.012	-	porphobilinogen	wild type D273-10B	Saccharomyces cerevisiae
2.5.1.61	0.0195	-	porphobilinogen	mutant B231	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.61	porphobilinogen	Saccharomyces cerevisiae	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.61	Saccharomyces cerevisiae	-	wild-type D273-10B, mutant B231	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.5.1.61	additional information	-	porphobilinogenase system	Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.61	4 porphobilinogen	in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75	Saccharomyces cerevisiae	uroporphyrinogen III + 4 NH3	-	?
2.5.1.61	4 porphobilinogen + H2O	-	Saccharomyces cerevisiae	hydroxylmethylbilane + 4 NH3	-	?
2.5.1.61	porphobilinogen	-	Saccharomyces cerevisiae	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.5.1.61	PBG-D	-	Saccharomyces cerevisiae
2.5.1.61	PBG-deaminase	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)