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Literature summary extracted from

  • Battersby, A.R.; Fookes, C.J.R.; Matcham, G.W.J.; McDonald, E.
    Biosynthesis of the pigments of life: formation of the macrocycle (1980), Nature, 285, 17-19.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.61 porphobilinogen Gallus gallus
-
 ?
-
 ?
2.5.1.61 porphobilinogen Euglena gracilis
-
 ?
-
 ?
2.5.1.61 porphobilinogen Propionibacterium freudenreichii subsp. shermanii
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.61 Euglena gracilis
-
-
-
2.5.1.61 Gallus gallus
-
-
-
2.5.1.61 Propionibacterium freudenreichii subsp. shermanii
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.61 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 mechanism Gallus gallus
a
2.5.1.61 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 mechanism Euglena gracilis
a
2.5.1.61 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 mechanism Propionibacterium freudenreichii subsp. shermanii
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Gallus gallus uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Euglena gracilis uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Propionibacterium freudenreichii subsp. shermanii uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Gallus gallus hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Euglena gracilis hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Propionibacterium freudenreichii subsp. shermanii hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 porphobilinogen
-
 Gallus gallus ?
-
 ?
2.5.1.61 porphobilinogen
-
 Euglena gracilis ?
-
 ?
2.5.1.61 porphobilinogen
-
 Propionibacterium freudenreichii subsp. shermanii ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.61 PBG-deaminase
-
 Gallus gallus
2.5.1.61 PBG-deaminase
-
 Euglena gracilis
2.5.1.61 PBG-deaminase
-
 Propionibacterium freudenreichii subsp. shermanii