Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shirahata, A.; Takahashi, N.; Beppu, T.; Hosoda, H.; Samejima, K.
    Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues (1993), Biochem. Pharmacol., 45, 1897-1903.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.5.1.22 medicine specific and marked decrease in spermine after diet containing N-(3-aminopropyl)cyclohexylamine Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 exo-2-aminonorbornane potent and selective, 98% inhibition at 0.1 mM in the presence of 1 mM of putrescine Rattus norvegicus
2.5.1.16 trans-4-Methylcyclohexylamine potent and selective, 98% inhibition at 0.1 mM in the presence of 1 mM of putrescine, in vitro. In vivo, intraperitoneal administration causes effective decrease in spermidine content in prostate, and oral administration causes 28%, 21% and 33% decrease in spermidine content in prostate, liver and kidney, respectively Rattus norvegicus
2.5.1.22 N-(3-aminopropyl)cyclohexylamine strong, selective Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus
-
 5'-methylthioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Rattus norvegicus
-
-
-
2.5.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 brain
-
 Rattus norvegicus
-
2.5.1.16 kidney
-
 Rattus norvegicus
-
2.5.1.16 liver
-
 Rattus norvegicus
-
2.5.1.16 prostate gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?