EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.22 | 5'-methylthioadenosine | strong | Bos taurus | |
2.5.1.22 | additional information | no inhibition by erythro-9-(2-hydroxy-3-nonyl)adenine, methylglyoxal-bis-(guanylhydrazone), aminoguanidine, guanethidine, L-canaline, MgCl2, KCl, diamines, polyamines, polyamine derivatives | Bos taurus | |
2.5.1.22 | N-ethylmaleimide | in the absence of sulfhydryl compounds | Bos taurus | |
2.5.1.22 | PCMB | in the absence of sulfhydryl compounds | Bos taurus | |
2.5.1.22 | putrescine | - |
Bos taurus | |
2.5.1.22 | S-adenosyl-L-homocysteine | not | Bos taurus | |
2.5.1.22 | S-adenosyl-L-methionine | not | Bos taurus | |
2.5.1.22 | spermine | product inhibition, weak | Bos taurus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.22 | 0.0006 | - |
S-adenosylmethioninamine | - |
Bos taurus | |
2.5.1.22 | 0.006 | - |
spermidine | - |
Bos taurus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.22 | additional information | no metal ion requirement | Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.5.1.22 | 45000 | - |
2 * 45000, SDS-PAGE | Bos taurus |
2.5.1.22 | 88000 | 90000 | brain, gel filtration, sedimentation equilibrium centrifugation | Bos taurus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.22 | S-adenosylmethioninamine + spermidine | Bos taurus | involved in polyamine biosynthetic pathway | 5'-methylthioadenosine + spermine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.22 | Bos taurus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.22 | spermine-Sepharose affinity chromatography | Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.22 | brain | - |
Bos taurus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.5.1.22 | 0.396 | - |
- |
Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.22 | additional information | overview | Bos taurus | ? | - |
? | |
2.5.1.22 | S-adenosylmethioninamine + spermidine | strictly specific for spermidine | Bos taurus | 5'-methylthioadenosine + spermine | - |
? | |
2.5.1.22 | S-adenosylmethioninamine + spermidine | involved in polyamine biosynthetic pathway | Bos taurus | 5'-methylthioadenosine + spermine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.5.1.22 | dimer | 2 * 45000, SDS-PAGE | Bos taurus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.22 | 37 | - |
- |
Bos taurus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.22 | additional information | - |
pI: 5.1, brain | Bos taurus |
2.5.1.22 | 7 | 8 | broad | Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.22 | additional information | no cofactor requirement | Bos taurus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.22 | 0.0003 | - |
5'-methylthioadenosine | - |
Bos taurus | |
2.5.1.22 | 0.0017 | - |
putrescine | - |
Bos taurus |