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Literature summary extracted from

  • Bhatia, M.B.; Grubmeyer, C.
    The role of divalent magnesium in activating the reaction catalyzed by orotate phosphoribosyltransferase (1993), Arch. Biochem. Biophys., 303, 321-325.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.10 0.027 0.0275 Orotate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 0.044
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 0.19
-
 Orotate methylester
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 2.63
-
 Uracil
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.10 Mg2+ requirement Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 Mg2+ mechanism Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 Mg2+ no orotate-Mg-complex formation, weak Mg-enzyme-complex Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 Mg2+ best with 2 mM Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 Mn2+ can replace Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 Mn2+ activation Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.10 Mn2+ mechanism Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.10 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.10 orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium orotidine 5'-phosphate + diphosphate
-
 ?
2.4.2.10 orotate methylester + phosphoribose diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + orotidine 4-methylester
-
 ?
2.4.2.10 uracil + phosphoribose diphosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + uridine
-
 ?