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Literature summary extracted from
- Properties of two unusual, and fluorescent, substrates of purine-nucleoside phosphorylase: 7-methylguanosine and 7-methylinosine (1986), Biochim. Biophys. Acta, 874, 355-363.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.1 | 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine | - |
Bos taurus |  |
| 2.4.2.1 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine | - |
Bos taurus | |
| 2.4.2.1 | 9-(2-hydroxyethoxymethyl)guanine | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.1 | 0.013 | - |
Inosine | - |
Bos taurus | |
| 2.4.2.1 | 0.015 | - |
7-methylguanosine | - |
Bos taurus | |
| 2.4.2.1 | 0.6 | - |
7-Methylinosine | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.1 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.4.2.1 | spleen | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.1 | 7-methylguanosine + phosphate | - |
Bos taurus | 7-methylguanine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | 7-methylinosine + phosphate | - |
Bos taurus | 7-methylhypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
| 2.4.2.1 | inosine + phosphate | - |
Bos taurus | hypoxanthine + alpha-D-ribose 1-phosphate | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.1 | 7 | 8.5 | - |
Bos taurus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.1 | 0.0021 | - |
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine | reaction with 7-methylguanosine | Bos taurus | |
| 2.4.2.1 | 0.0062 | - |
1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine | reaction with inosine | Bos taurus | |
| 2.4.2.1 | 0.024 | - |
9-(1,3-dihydroxy-2-propoxymethyl)guanine | reaction with 7-methylguanosine | Bos taurus | |
| 2.4.2.1 | 0.027 | - |
9-(1,3-dihydroxy-2-propoxymethyl)guanine | reaction with inosine | Bos taurus | |
| 2.4.2.1 | 0.058 | - |
9-(2-hydroxyethoxymethyl)guanine | reaction with 7-methylguanosine | Bos taurus | |
| 2.4.2.1 | 0.068 | - |
9-(2-hydroxyethoxymethyl)guanine | reaction with inosine | Bos taurus | |
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