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Literature summary extracted from

  • Villagomez-Castro, J.C.; Calvo-Mendez, C.; Vargas-Rodriguez, L.; Flores-Carreon, A.; Lopez-Romero, E.
    Entamoeba histolytica: solubilization and biochemical characterization of dolichol phosphate mannose synthase, an essential enzyme in glycoprotein biosynthesis (1998), Exp. Parasitol., 88, 111-120.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.83 ADP
-
 Entamoeba histolytica
2.4.1.83 AMP
-
 Entamoeba histolytica
2.4.1.83 ATP
-
 Entamoeba histolytica
2.4.1.83 GDP strong Entamoeba histolytica
2.4.1.83 GMP
-
 Entamoeba histolytica
2.4.1.83 GTP strong Entamoeba histolytica
2.4.1.83 UDP
-
 Entamoeba histolytica
2.4.1.83 UMP
-
 Entamoeba histolytica
2.4.1.83 UTP
-
 Entamoeba histolytica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.83 0.0041
-
 GDPmannose
-
 Entamoeba histolytica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.83 Mg2+ divalent cation required for dolichol phosphate mannose: 2.5-7.5 mM Mg2+ or 2-3 mM Mn2+. Mg2+ is a better activator than Mn2+ in the reverse reaction Entamoeba histolytica
2.4.1.83 Mn2+ divalent cation required for synthesis of dolichyl D-mannosyl phosphate: 2.5-7.5 mM Mg2+ or 2-3 mM Mn2+. Mg2+ is a better activator than Mn2+ in the reverse reaction Entamoeba histolytica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.83 GDPmannose + dolichyl phosphate Entamoeba histolytica essential enzyme in glycoprotein biosynthesis GDP + dolichyl D-mannosyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.83 Entamoeba histolytica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.83 GDPmannose + dolichyl phosphate
-
 Entamoeba histolytica GDP + dolichyl D-mannosyl phosphate
-
 r
2.4.1.83 GDPmannose + dolichyl phosphate essential enzyme in glycoprotein biosynthesis Entamoeba histolytica GDP + dolichyl D-mannosyl phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.83 7.5 8 potassium phosphate or Tris-HCl buffer Entamoeba histolytica

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.83 6.5 8.5 pH 6.5: about 80% of maximal activity, pH 8.5: about 54% of maximal activity Entamoeba histolytica