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Literature summary extracted from

  • Jensen, J.W.; Schutzbach, J.S.
    Activation of dolichyl-phospho-mannose synthase by phospholipids (1985), Eur. J. Biochem., 153, 41-48.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.83 additional information optimally active in a phospholipid matrix that contains some component phospholipids that prefer non-bilayer structural organization in isolation Rattus norvegicus

General Stability

EC Number General Stability Organism
2.4.1.83 unstable in presence of detergent Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.83 GDP 0.0013 mM, 50% inhibition Rattus norvegicus
2.4.1.83 GMP 0.016 mM, 50% inhibition Rattus norvegicus
2.4.1.83 GTP 0.003 mM, 50% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.83 0.0003
-
 dolichyl phosphate
-
 Rattus norvegicus
2.4.1.83 0.00069
-
 GDPmannose
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.83 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.83 Mn2+ divalent cation required, maximal stimulation at 2.5 mM Mn2+ Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.83 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.83
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.83 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.83 0.07
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.83 GDPmannose + dolichyl phosphate
-
 Rattus norvegicus GDP + dolichyl D-mannosyl phosphate
-
 ?