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Literature summary extracted from

  • Navaratnam, N.; Findlay, J.B.C.; Keen, J.N.; Watkins, W.M.
    Purification, properties and partial amino acid sequence of the blood-group-A-gene-associated alpha-3-N-acetylgalactosaminyltransferase from human gut mucosal tissue (1990), Biochem. J., 271, 93-98.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.40 CDP
-
 Homo sapiens
2.4.1.40 Fluorescein mercuriacetate
-
 Homo sapiens
2.4.1.40 GDP weak Homo sapiens
2.4.1.40 N-ethylmaleimide weak Homo sapiens
2.4.1.40 UDP
-
 Homo sapiens
2.4.1.40 UMP
-
 Homo sapiens
2.4.1.40 uridine
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.40 Mn2+ maximal activity with 10 mM Mn2+ Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.40 40000
-
 x * 40000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.40 additional information Homo sapiens transfers N-acetylgalactosamine from UDP-N-acetylgalactosamine to H-active structures to form A determinants ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.40 Homo sapiens
-
 blood group A
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.40 blood group A Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.40 gut mucosa
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.40 7
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.40 additional information effective acceptor substrates contain a subterminal beta-galactosyl residue substituted at the O-2 position with fucose Homo sapiens ?
-
 ?
2.4.1.40 additional information transfers N-acetylgalactosamine from UDP-N-acetylgalactosamine to H-active structures to form A determinants Homo sapiens ?
-
 ?
2.4.1.40 UDP-N-acetyl-D-galactosamine + glycoprotein alpha-L-fucosyl-1,2-D-galactose
-
 Homo sapiens UDP + glycoprotein N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1,2]-D-galactose
-
 ?
2.4.1.40 UDP-N-acetyl-D-galactosamine + lacto-N-fucopentaose I i.e. Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[lacto-N-fucopentaose I]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.40 ? x * 40000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.40 7 7.4
-
 Homo sapiens