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Literature summary extracted from

  • Gotoh, M.; Yada, T.; Sato, T.; Akashima, T.; Iwasaki, H.; Mochizuki, H.; Inaba, N.; Togayachi, A.; Kudo, T.; Watanabe, H.; Kimata, K.; Narimatsu, H.
    Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine (2002), J. Biol. Chem., 277, 38179-38188.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.226 enzyme domain containing beta-3-glycosyltransferase motifs, expressed in COS-7 cells ATCCCRL 1651 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.226 0.0653
-
 chondroitin sulfate undecasaccharide
-
 Homo sapiens
2.4.1.226 0.0824
-
 UDP-glucuronic acid
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.226 Mn2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.226 Homo sapiens Q9P2E5 further cDNA: Kazusa DNA Research Institute number KIAA1402
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.226
-
 Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.226 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.226 additional information the glucuronic acid transfer rate roughly increases with increasing chain length Homo sapiens ?
-
 ?
2.4.1.226 additional information no substrates: chondroitin, chondroitin sulfate, dermatan sulfate, N-acetylheparosan, hyaluronan, heparan sulfate, heparin, hyaluronan heptasaccharides Homo sapiens ?
-
 ?
2.4.1.226 UDP-alpha-D-glucuronic acid + N-acetyl-D-galactosaminyl chondroitin polysaccharide polysaccharide substrate used after beta-glucuronidase treatment Homo sapiens UDP + beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-chondroitin polysaccharide
-
 ?
2.4.1.226 UDP-glucuronic acid + chondroitin heptasaccharide heptasaccharide having a N-acetylgalactosamine residue at its non-reducing terminus Homo sapiens ?
-
 ?
2.4.1.226 UDP-glucuronic acid + chondroitin sulfate heptasaccharide heptasaccharide having a N-acetylgalactosamine residue at its non-reducing terminus Homo sapiens ?
-
 ?
2.4.1.226 UDP-glucuronic acid + chondroitin sulfate undecasaccharide
-
 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.226 37
-
 enzyme assay Homo sapiens