EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.223 | expression in COS-1 cells, truncated form , lacking the first 58 N-terminal amino acids | Caenorhabditis elegans |
2.4.1.224 | DV1, expression of soluble form of rib-2 protein in COS-1 cells | Caenorhabditis elegans |
2.4.1.224 | expression of soluble form of EXT1 and EXT2 proteins in COS-1 cells | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.1.224 | 110000 | - |
expressed fusion protein from COS-1after N-glycosidase treatment, SDS-PAGE | Caenorhabditis elegans |
2.4.1.224 | 130000 | - |
expressed fusion protein from COS-1, SDS-PAGE | Caenorhabditis elegans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan | Caenorhabditis elegans | initiation and elongation of heparan sulfate | UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan | - |
? | |
2.4.1.224 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | Homo sapiens | elongation of growing chains of heparin and heparan sulfate, tumor suppressor | UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
? | |
2.4.1.224 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | Caenorhabditis elegans | elongation of growing chains of heparin and heparan sulfate, tumor suppressor | UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.223 | Caenorhabditis elegans | - |
gene rib-2 | - |
2.4.1.224 | Caenorhabditis elegans | - |
- |
- |
2.4.1.224 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.4.1.224 | glycoprotein | N-linked glycosylation, molecular weight of expressed fusion protein is reduced from 1300000 to 110000 by N-glycosidase treatment | Caenorhabditis elegans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan | initiation and elongation of heparan sulfate | Caenorhabditis elegans | UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan | - |
? | |
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl | - |
Caenorhabditis elegans | UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl | - |
? | |
2.4.1.224 | additional information | EXT1 and EXT2 proteins also acts as beta(1,4)-glucuronyltransferase (EC 2.4.1.225) | Homo sapiens | ? | - |
? | |
2.4.1.224 | additional information | different acceptors tested for activity with UDP-N-acetyl-D-glucosamine | Homo sapiens | ? | - |
? | |
2.4.1.224 | additional information | different acceptors tested for activity with UDP-N-acetyl-D-glucosamine | Caenorhabditis elegans | ? | - |
? | |
2.4.1.224 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
Homo sapiens | UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
? | |
2.4.1.224 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
Caenorhabditis elegans | UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
? | |
2.4.1.224 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | elongation of growing chains of heparin and heparan sulfate, tumor suppressor | Homo sapiens | UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
? | |
2.4.1.224 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | elongation of growing chains of heparin and heparan sulfate, tumor suppressor | Caenorhabditis elegans | UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.224 | More | - |
- |