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Literature summary extracted from

  • Mojarrabi, B.; Butler, R.; Mackenzie, P.I.
    cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3 (1996), Biochem. Biophys. Res. Commun., 225, 785-790.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 UGT1A3 expressed in COS-7 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 overview
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 colon
-
 Homo sapiens
-
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 12-hydroxybenzo[a]pyrene + UDP-glucuronate glucuronidated by UGT1A3, inactive towards benz[a]pyrene trans 4,5 and 7,8 dihydrodiols Homo sapiens UDP + benzo[a]pyren-12-yl-beta-D-glucuronide
-
 ?
2.4.1.17 2-hydroxyestrone + UDPglucuronate glucuronidated by UGT1A3 and HGT1A9 Homo sapiens 2-hydroxyestrone 2-O-glucuronide + UDP
-
 ?
2.4.1.17 5-hydroxybenzo[a]pyrene + UDPglucuronate glucuronidated by UGT1A3 Homo sapiens UDP + 5-hydroxybenzo[a]pyrene O-glucuronide
-
 ?
2.4.1.17 estriol + UDPglucuronate UGT1A3 inactive Homo sapiens UDP + estriol-16 alpha-glucuronide
-
 ?
2.4.1.17 estrone + UDPglucuronate glucuronidated by UGT1A3 and HGT1A9 Homo sapiens UDP + estrone 3-O-glucuronide
-
 ?
2.4.1.17 additional information 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids Homo sapiens ?
-
 ?
2.4.1.17 additional information UGT1A3 inactive towards 4-hydroxyestrone and 16 alpha-hydroxyestrone Homo sapiens ?
-
 ?
2.4.1.17 N-hydroxy-2-acetylaminofluorene + UDPglucuronate glucuronidated by UGT1A3 in preference to the ring-hydroxylated derivatives Homo sapiens UDP + N-hydroxy-2-acetylaminofluorene O-glucuronide
-
 ?