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Literature summary extracted from

  • King, C.D.; Green, M.D.; Rios, G.R.; Coffman, B.L.; Owens, I.S.; Bishop, W.P.; Tephly, T.R.
    The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1 (1996), Arch. Biochem. Biophys., 332, 92-100.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.014
-
 bilirubin apparent Km for UGT1.1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.4.1.17 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.4.1.17 nuclear membrane
-
 Homo sapiens 31965
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 bilirubin + UDPglucuronate Homo sapiens
-
 UDP + bilirubin O-glucuronide
-
 ?
2.4.1.17 bilirubin + UDPglucuronate Rattus norvegicus
-
 UDP + bilirubin O-glucuronide
-
 ?
2.4.1.17 additional information Homo sapiens certain endogenous estrogens glucuronidated by UGT1.1 at 3-hydroxyl group of the A ring of steroids ?
-
 ?
2.4.1.17 additional information Rattus norvegicus certain endogenous estrogens glucuronidated by UGT1.1 at 3-hydroxyl group of the A ring of steroids ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-
2.4.1.17 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 anthraflavic acid + UDPglucuronate
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 anthraflavic acid + UDPglucuronate
-
 Rattus norvegicus UDP + ?
-
 ?
2.4.1.17 apigenin + UDPglucuronate
-
 Homo sapiens UDP + apigenin O-glucuronide
-
 ?
2.4.1.17 apigenin + UDPglucuronate
-
 Rattus norvegicus UDP + apigenin O-glucuronide
-
 ?
2.4.1.17 bilirubin + UDPglucuronate
-
 Homo sapiens bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 bilirubin + UDPglucuronate
-
 Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 bilirubin + UDPglucuronate
-
 Homo sapiens UDP + bilirubin O-glucuronide
-
 ?
2.4.1.17 bilirubin + UDPglucuronate
-
 Rattus norvegicus UDP + bilirubin O-glucuronide
-
 ?
2.4.1.17 buprenorphine + UDPglucuronate
-
 Homo sapiens UDP + buprenorphine O-glucuronide
-
 ?
2.4.1.17 buprenorphine + UDPglucuronate
-
 Rattus norvegicus UDP + buprenorphine O-glucuronide
-
 ?
2.4.1.17 digitoxigenin + UDPglucuronate
-
 Rattus norvegicus UDP + digitoxigenin O-glucuronide
-
 ?
2.4.1.17 additional information 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids Homo sapiens ?
-
 ?
2.4.1.17 additional information simple planar phenols, anthraquinones and opioid compounds glucuronidated by UGT1.1, aliphatic and monoterpenoid alcohols and amines not glucuronidated Homo sapiens ?
-
 ?
2.4.1.17 additional information simple planar phenols, anthraquinones and opioid compounds glucuronidated by UGT1.1, aliphatic and monoterpenoid alcohols and amines not glucuronidated Rattus norvegicus ?
-
 ?
2.4.1.17 additional information certain endogenous estrogens glucuronidated by UGT1.1 at 3-hydroxyl group of the A ring of steroids Homo sapiens ?
-
 ?
2.4.1.17 additional information certain endogenous estrogens glucuronidated by UGT1.1 at 3-hydroxyl group of the A ring of steroids Rattus norvegicus ?
-
 ?
2.4.1.17 phenolphthalein + UDPglucuronate
-
 Rattus norvegicus UDP + phenolphthalein O-glucuronide
-
 ?
2.4.1.17 quercetin + UDPglucuronate
-
 Homo sapiens UDP + quercetin O-glucuronide
-
 ?
2.4.1.17 quercetin + UDPglucuronate
-
 Rattus norvegicus UDP + quercetin O-glucuronide
-
 ?