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Literature summary extracted from

  • Jansen, P.L.M.; Mulder, G.J.; Burchell, B.; Bock, K.W.
    New developments in glucuronidation research: report of a workshop on "glucuronidation, its role in health and disease" (1992), Hepatology, 15, 532-544.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 3-methylcholanthrene induces glucuronidation of planar phenols Rattus norvegicus
2.4.1.17 Phenobarbital
-
 Homo sapiens
2.4.1.17 Phenobarbital induces bilirubin glucuronidation Rattus norvegicus
2.4.1.17 UDP-N-acetylglucosamine presumed physiological activator Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expressed in COS-7 cells Rattus norvegicus
2.4.1.17 several UGT cloned. Persistently increased expression of phenol-UGT in rat hepatocyte nodules, hepatoma H4IIE cells and various rat liver epithelial cell lines. Expressed in human lung carcinoma A549 cells and human breast cancer MCF7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 2,2,2-triphenyl-UDP selective inhibitor Rattus norvegicus
2.4.1.17 7,7,7-Triphenylheptanoic acid competitive to bilirubin Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 endoplasmic reticulum membrane
-
 Rattus norvegicus 5789
-
2.4.1.17 endoplasmic reticulum membrane sequencing data indicate that the enzymes are anchored in the membrane by a carboxy-terminal hydrophobic domain, with a bulk of the polypeptide chain located within the cisternal lumen of the endoplasmic reticulum Homo sapiens 5789
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 overview
-
2.4.1.17 Rattus norvegicus
-
 overview
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.17 additional information Gunn rat strain, inducible phenol-UGT synthesized in the truncated form is not the result of a posttranslational modification Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.17 two isozymes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 bilirubin + UDPglucuronate
-
 Homo sapiens bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 bilirubin + UDPglucuronate expressed after birth Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
2.4.1.17 additional information substrate specificity determinates by amino acid sequences in the variable amino-terminal half of the enzyme molecule Rattus norvegicus ?
-
 ?
2.4.1.17 planar phenols + UDPglucuronate expressed before birth Rattus norvegicus UDP + phenylglucuronides
-
 ?