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Literature summary extracted from

  • Matern, H.; Matern, S.; Schelzig, C.; Gerok, W.
    Bile acid UDP-glucoronyltransferase from human liver. Properties and studies on aglycone substrate specificity (1980), FEBS Lett., 118, 251-254.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 Clofibrate
-
 Homo sapiens
2.4.1.17 Digitonin 0.6 mg/mg liver protein, 1.8fold activation using non-saturated substrate concentration Homo sapiens
2.4.1.17 Triton X-100 0.01%, 1.6fold activation using non-saturated substrate concentration Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 4-nitrophenol uncompetitive to chenodeoxycholic acid Homo sapiens
2.4.1.17 bilirubin competitive to chenodeoxycholic acid Homo sapiens
2.4.1.17 chenodeoxycholic acid inhibits glucuronidation of bilirubin Homo sapiens
2.4.1.17 Digitonin inhibition above 0.6 mg/mg protein; no effect at saturating substrate concentrations Homo sapiens
2.4.1.17 estradiol competitive to chenodeoxycholic acid Homo sapiens
2.4.1.17 Fe2+
-
 Homo sapiens
2.4.1.17 Ni2+
-
 Homo sapiens
2.4.1.17 testosterone noncompetitive to chenodeoxycholic acid Homo sapiens
2.4.1.17 Triton X-100 above 0.01% v/v; no effect at saturating substrate concentrations Homo sapiens
2.4.1.17 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.083
-
 chenodeoxycholic acid
-
 Homo sapiens
2.4.1.17 0.96
-
 UDPglucuronic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ 140% stimulated by 5mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 chenodeoxycholic acid + UDP-glucuronate
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 cholic acid + UDPglucuronate
-
 Homo sapiens cholic acid O-glucuronide
-
 ?
2.4.1.17 lithocholic acid + UDPglucuronate
-
 Homo sapiens UDP + ?
-
 ?
2.4.1.17 additional information 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids Homo sapiens ?
-
 ?
2.4.1.17 additional information affinity of unconjugated bile acids decrease with increasing number of hydroxyl groups in the bile acid skeleton Homo sapiens ?
-
 ?
2.4.1.17 ursodeoxycholic acid + UDPglucuronate
-
 Homo sapiens UDP + ursodeoxycholic acid O-glucuronide
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 6.7
-
 chenodeoxycholic acid Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.1.17 6 8 substrate chenodeoxycholic acid Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 0.26
-
 estradiol
-
 Homo sapiens
2.4.1.17 0.28
-
 bilirubin
-
 Homo sapiens
2.4.1.17 2.2
-
 testosterone
-
 Homo sapiens