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Literature summary extracted from

  • Gregory, D.H.; Strickland, R.D.
    Solubilization and characterization of hepatic bilirubin UDP-glucuronyltransferase (1973), Biochim. Biophys. Acta, 327, 36-45.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 UDP-N-acetylglucosamine inhibition at high concentration Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 membrane
-
 Rattus norvegicus 16020
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ 5-20 mM essential, no regulation of the concentration required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.4.1.17 4°C, solubilized enzyme stable for 7 days, concentrated form loses 12% of activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 bilirubin + UDPglucuronate
-
 Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
-
 Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.1.17 40
-
 inactivation above Rattus norvegicus
2.4.1.17 45
-
 3 min, 80% reduced activity Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.8
-
 bilirubin Rattus norvegicus