BRENDA - Enzyme Database

Control of dolichyl phosphoglucose formation in human liver microsomes. Kinetic and inhibition studies of nucleosides, nucleotides and analogues of UDPglucose

Matern, H.; Matern, S.; Biochim. Biophys. Acta 1004, 67-72 (1989)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.1.117
UDP
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.1.117
0.00015
-
UDP-glucose
pH 7.2
Homo sapiens
2.4.1.117
0.00033
-
UDP-glucose
pH 5.3
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.4.1.117
microsome
-
Homo sapiens
-
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.1.117
Ca2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
2.4.1.117
Co2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
2.4.1.117
Mg2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
2.4.1.117
Mn2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.1.117
Homo sapiens
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
2.4.1.117
UDP-alpha-D-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate
sequential mechanism
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.1.117
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.1.117
UDP-glucose + dolichyl phosphate
-
488485
Homo sapiens
UDP + dolichyl beta-D-glucosyl phosphate
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.4.1.117
5.3
-
second optimum at pH 7.2
Homo sapiens
2.4.1.117
7.2
-
second optimum at pH 5.3
Homo sapiens
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.4.1.117
0.1
-
UDP
at pH 7.2
Homo sapiens
2.4.1.117
0.17
-
UDP
at pH 5.3
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.1.117
UDP
-
Homo sapiens
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.4.1.117
0.1
-
UDP
at pH 7.2
Homo sapiens
2.4.1.117
0.17
-
UDP
at pH 5.3
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.4.1.117
0.00015
-
UDP-glucose
pH 7.2
Homo sapiens
2.4.1.117
0.00033
-
UDP-glucose
pH 5.3
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.4.1.117
microsome
-
Homo sapiens
-
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.1.117
Ca2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
2.4.1.117
Co2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
2.4.1.117
Mg2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
2.4.1.117
Mn2+
divalent cation required, maximum stimulation in presence of Ca2+. Co2+, Mg2+ or Mn2+ can replace Ca2+
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.1.117
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.1.117
UDP-glucose + dolichyl phosphate
-
488485
Homo sapiens
UDP + dolichyl beta-D-glucosyl phosphate
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.4.1.117
5.3
-
second optimum at pH 7.2
Homo sapiens
2.4.1.117
7.2
-
second optimum at pH 5.3
Homo sapiens