Literature summary extracted from

Mayer, R.J.; Louis-Flamberg, P.; Elliott, J.D.; Fisher, M.; Leber, J.
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones (1990), Biochem. Biophys. Res. Commun., 169, 610-616.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.3.10	L-659,699	antibiotic 1233A	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	Rattus norvegicus	-	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.3.10	Rattus norvegicus	-	rat	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.3.10	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.3.10	acetyl-CoA + acetoacetyl-CoA + H2O	-	Rattus norvegicus	(S)-3-hydroxy-3-methylglutaryl-CoA + CoA	-	?

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Release 2023.1 (January 2023)