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Literature summary extracted from

  • Karahalios, P.; Mamos, P.; Karigiannis, G.; Kalpaxis, D.L.
    Structure/function correlation of spermine-analog-induced modulation of peptidyltransferase activity (1998), Eur. J. Biochem., 258, 437-444.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.12 N1,N12-Diacetylspermine both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration Escherichia coli
2.3.2.12 N1,N12-dipivaloylspermine both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration Escherichia coli
2.3.2.12 N1-acetylspermine both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.12 N1,N12-Diacetylspermine both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration Escherichia coli
2.3.2.12 N1,N12-dipivaloylspermine both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration Escherichia coli
2.3.2.12 N1-acetylspermine both stimulatory and inhibitory effects at the kinetic phase in the presence of the factors washable from ribosomes, depending on ligand concentration Escherichia coli
2.3.2.12 spermine
-
 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.12 ribosome
-
 Escherichia coli 5840
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.12 Mg2+
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 AcPhe-tRNA + puromycin
-
 Escherichia coli tRNA + AcPhe-puromycin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.12 25
-
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.12 3.2
-
 spermine
-
 Escherichia coli
2.3.2.12 5
-
 N1-acetylspermine
-
 Escherichia coli
2.3.2.12 12.9
-
 N1,N12-dipivaloylspermine
-
 Escherichia coli
2.3.2.12 33
-
 N1,N12-Diacetylspermine
-
 Escherichia coli