Literature summary extracted from

Ioannou, M.; Coutsogeorgopoulos, C.; Synetos, D.
Kinetics of inhibition of rabbit reticulocyte peptidyltransferase by anisomycin and sparsomycin (1998), Mol. Pharmacol., 53, 1089-1096.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.2.12	anisomycin	-	Oryctolagus cuniculus
2.3.2.12	sparsomycin	-	Oryctolagus cuniculus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.3.2.12	ribosome	80S ribosomes	Oryctolagus cuniculus	5840	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.12	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.2.12	reticulocyte	unwashed ribosomes	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.2.12	AcPhe-tRNA + puromycin	AcPhe-tRNA-polyU-80S ribosome complex	Oryctolagus cuniculus	tRNA + AcPhe-puromycin	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.3.2.12	25	-	enzyme assay, disk reaction	Oryctolagus cuniculus

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.3.2.12	0.00013	-	sparsomycin	from the competitive phase of the inhibition	Oryctolagus cuniculus
2.3.2.12	0.00022	-	sparsomycin	-	Oryctolagus cuniculus
2.3.2.12	0.00067	-	anisomycin	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)