Literature summary extracted from

Drainas D.; Kalpaxis, D.L.; Coutsogeorgopoulos, C.
Inhibition of ribosomal peptidyltransferase by chloramphenicol. Kinetic studies (1987), Eur. J. Biochem., 164, 53-58.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.2.12	chloramphenicol	-	Escherichia coli
2.3.2.12	Tevenel	-	Escherichia coli
2.3.2.12	Thiamphenicol	-	Escherichia coli

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.3.2.12	ribosome	-	Escherichia coli	5840	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.12	Escherichia coli	-	B cells	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.2.12	AcPhe-tRNA + puromycin	AcPhe-tRNA-polyU-70S ribosome complex	Escherichia coli	tRNA + AcPhe-puromycin	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.3.2.12	0.000045	-	Thiamphenicol	-	Escherichia coli
2.3.2.12	0.00007	-	chloramphenicol	initial phase of competitive inhibition	Escherichia coli
2.3.2.12	0.00017	-	Tevenel	-	Escherichia coli

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Release 2023.1 (January 2023)