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Literature summary extracted from

  • Namboodiri, M.A.A.; Dubbels, R.; Klein, D.C.
    Arylalkylamine N-acetyltransferase from mammalian pineal gland (1987), Methods Enzymol., 142, 583-590.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.87 acetyl-CoA stabilizes Rattus norvegicus
2.3.1.87 acetyl-CoA stabilizes Ovis aries
2.3.1.87 ATP stabilizes Rattus norvegicus
2.3.1.87 ATP stabilizes Ovis aries
2.3.1.87 freezing markedly decreases activity Rattus norvegicus
2.3.1.87 freezing markedly decreases activity Ovis aries
2.3.1.87 polyanions stabilize Rattus norvegicus
2.3.1.87 polyanions stabilize Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.87 Disulfides in vivo and in vitro, reversible by dithiothreitol Ovis aries
2.3.1.87 Disulfides in vivo and in vitro, reversible by dithiothreitol Rattus norvegicus
2.3.1.87 Peptides containing a disulfide bond
-
 Ovis aries
2.3.1.87 Peptides containing a disulfide bond
-
 Rattus norvegicus
2.3.1.87 Zn2+ at low concentration Ovis aries
2.3.1.87 Zn2+ at low concentration Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.87 additional information activation by salts as a function of ionic strength Rattus norvegicus
2.3.1.87 additional information activation by salts as a function of ionic strength Ovis aries

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.87 additional information
-
-
 Rattus norvegicus
2.3.1.87 additional information
-
 multiple forms, from 10000 Da via 39000 Da to 100000 Da Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.87 acetyl-CoA + serotonin Rattus norvegicus initial reaction in melatonin synthesis from serotonin CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + serotonin Ovis aries initial reaction in melatonin synthesis from serotonin CoA + N-acetylserotonin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Ovis aries
-
-
-
2.3.1.87 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.87
-
 Rattus norvegicus
2.3.1.87 affinity chromatography on Sepharose CoA Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.87 pineal gland
-
 Rattus norvegicus
-
2.3.1.87 pineal gland
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.87 0.000195
-
-
 Ovis aries

Storage Stability

EC Number Storage Stability Organism
2.3.1.87 0-2°C, up to 72 h Rattus norvegicus
2.3.1.87 0-2°C, up to 72 h Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + beta-phenylethylamine
-
 Rattus norvegicus CoA + N-(2-phenylethyl)-acetaminde
-
 ?
2.3.1.87 acetyl-CoA + beta-phenylethylamine
-
 Ovis aries CoA + N-(2-phenylethyl)-acetaminde
-
 ?
2.3.1.87 acetyl-CoA + serotonin i.e. 5-hydroxytryptamine Rattus norvegicus CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + serotonin i.e. 5-hydroxytryptamine Ovis aries CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + serotonin initial reaction in melatonin synthesis from serotonin Rattus norvegicus CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + serotonin initial reaction in melatonin synthesis from serotonin Ovis aries CoA + N-acetylserotonin
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Rattus norvegicus CoA + N-acetyltryptamine
-
 ?
2.3.1.87 acetyl-CoA + tryptamine
-
 Ovis aries CoA + N-acetyltryptamine
-
 ?
2.3.1.87 additional information arylamines, such as aniline or p-phenetidine are very poor substrates Rattus norvegicus ?
-
 ?
2.3.1.87 additional information arylamines, such as aniline or p-phenetidine are very poor substrates Ovis aries ?
-
 ?