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Literature summary extracted from

  • Kispal, G.; Cseko, J.; Alkonyi, I.; Sandor, A.
    Isolation and characterization of carnitine acetyltransferase from S. cerevisiae (1991), Biochim. Biophys. Acta, 1085, 217-222.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.0177
-
 acetyl-CoA
-
 Saccharomyces cerevisiae
2.3.1.7 0.076
-
 acetyl-CoA
-
 Saccharomyces cerevisiae
2.3.1.7 0.17
-
 L-(-)-carnitine
-
 Saccharomyces cerevisiae
2.3.1.7 0.23
-
 L-(-)-carnitine
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrial matrix
-
 Rattus norvegicus 5759
-
2.3.1.7 mitochondrial matrix
-
 Saccharomyces cerevisiae 5759
-
2.3.1.7 mitochondrial matrix
-
 Candida tropicalis 5759
-
2.3.1.7 mitochondrial matrix
-
 Torulopsis bovina 5759
-
2.3.1.7 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.7 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.7 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
2.3.1.7 mitochondrion
-
 Candida tropicalis 5739
-
2.3.1.7 mitochondrion
-
 Torulopsis bovina 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.7 65000
-
 6 * 65000, SDS-PAGE Saccharomyces cerevisiae
2.3.1.7 400000
-
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Homo sapiens
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Rattus norvegicus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Saccharomyces cerevisiae
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Bos taurus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Candida tropicalis
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Columba sp.
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Homo sapiens
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Rattus norvegicus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Saccharomyces cerevisiae
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Bos taurus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Candida tropicalis
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Columba sp.
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Torulopsis bovina
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Homo sapiens
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Rattus norvegicus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Saccharomyces cerevisiae
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Bos taurus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Candida tropicalis
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Columba sp.
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Torulopsis bovina
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Homo sapiens
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Rattus norvegicus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Bos taurus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Candida tropicalis
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Columba sp.
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Saccharomyces cerevisiae acetate metabolism, enzyme transports activated acetyl group from the cytosol into the mitochondrial matrix acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Bos taurus
-
 bovine
-
2.3.1.7 Candida tropicalis
-
 yeast
-
2.3.1.7 Columba sp.
-
 pigeon
-
2.3.1.7 Homo sapiens
-
 human
-
2.3.1.7 Rattus norvegicus
-
 rat
-
2.3.1.7 Saccharomyces cerevisiae
-
 baker's yeast
-
2.3.1.7 Torulopsis bovina
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 breast muscle
-
 Columba sp.
-
2.3.1.7 brown adipose tissue
-
 Rattus norvegicus
-
2.3.1.7 heart
-
 Homo sapiens
-
2.3.1.7 heart
-
 Rattus norvegicus
-
2.3.1.7 heart
-
 Bos taurus
-
2.3.1.7 heart
-
 Columba sp.
-
2.3.1.7 liver
-
 Homo sapiens
-
2.3.1.7 liver
-
 Rattus norvegicus
-
2.3.1.7 liver
-
 Columba sp.
-
2.3.1.7 muscle
-
 Rattus norvegicus
-
2.3.1.7 muscle
-
 Columba sp.
-
2.3.1.7 semen
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.7 200
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Saccharomyces cerevisiae O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Bos taurus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Candida tropicalis O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Saccharomyces cerevisiae O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Bos taurus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Candida tropicalis O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Torulopsis bovina O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Homo sapiens acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Rattus norvegicus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Saccharomyces cerevisiae acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Bos taurus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Candida tropicalis acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Columba sp. acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Torulopsis bovina acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Homo sapiens acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Rattus norvegicus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Saccharomyces cerevisiae acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Bos taurus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Candida tropicalis acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Columba sp. acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Torulopsis bovina acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Saccharomyces cerevisiae acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Bos taurus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida tropicalis acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Torulopsis bovina acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Bos taurus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida tropicalis acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH acetate metabolism, enzyme transports activated acetyl group from the cytosol into the mitochondrial matrix Saccharomyces cerevisiae acetyl-CoA + carnitine
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.7 hexamer 6 * 65000, SDS-PAGE Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.7 7.5 8
-
 Saccharomyces cerevisiae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.7 7 9
-
 Saccharomyces cerevisiae

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.3.1.7 6 9 below pH 6.0 enzyme undergoes irreversible inactivation Saccharomyces cerevisiae