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Literature summary extracted from

  • Yanoshita, R.; Chang, H.W.; Son, K.H.; Kudo, I.; Samejina, Y.
    Inhibition of lysoPAF acetyltransferase activity by flavonoids (1996), Inflamm. Res., 45, 546-549.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 4-(1-Naphthylvinyl)pyridine IC50: 0.043 mM Rattus norvegicus
2.3.1.67 luteolin IC50: 0.045 mM Rattus norvegicus
2.3.1.67 quercetin IC50: 0.08 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 RBL-2H3 cell mastocytoma cell, mucosal-type Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.67 0.0021
-
 A23187 stimulated cell Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
-
 Rattus norvegicus CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 6.9
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.67 0.043
-
 IC50: 0.043 mM Rattus norvegicus 4-(1-Naphthylvinyl)pyridine
2.3.1.67 0.045
-
 IC50: 0.045 mM Rattus norvegicus luteolin
2.3.1.67 0.08
-
 IC50: 0.08 mM Rattus norvegicus quercetin