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Literature summary extracted from

  • Yamazaki, R.; Sugatani, J.; Fujii, I.; Kuroyanagi, M.; Umehara, K.; Ueno, A.; Suzuki, Y.; Miwa, M.
    Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex (1994), Biochem. Pharmacol., 47, 995-1006.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 acetyl-salicylic acid weak inhibition Rattus norvegicus
2.3.1.67 baicalein IC50: 0.148 mM Rattus norvegicus
2.3.1.67 chiyusaponin IC50: 0.2 mM Rattus norvegicus
2.3.1.67 honokiol IC50: 0.06 mM, reversible inhibition Homo sapiens
2.3.1.67 honokiol IC50: 0.15 mM Rattus norvegicus
2.3.1.67 indomethacin weak inhibition at 1 mM Rattus norvegicus
2.3.1.67 magnolol IC50: 0.07 mM, reversible inhibition Homo sapiens
2.3.1.67 magnolol IC50: 0.15 mM Rattus norvegicus
2.3.1.67 nordihydroguaiaretic acid IC50: 0.06 mM Homo sapiens
2.3.1.67 nordihydroguaiaretic acid IC50: 0.29 mM Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.67 membrane
-
 Homo sapiens 16020
-
2.3.1.67 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Homo sapiens
-
-
-
2.3.1.67 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + hexadecyl-lyso-sn-glycero-3-phosphocholine
-
 Homo sapiens CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Homo sapiens
2.3.1.67 37
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.67 0.06
-
 IC50: 0.06 mM Homo sapiens nordihydroguaiaretic acid
2.3.1.67 0.06
-
 IC50: 0.06 mM, reversible inhibition Homo sapiens honokiol
2.3.1.67 0.07
-
 IC50: 0.07 mM, reversible inhibition Homo sapiens magnolol
2.3.1.67 0.148
-
 IC50: 0.148 mM Rattus norvegicus baicalein
2.3.1.67 0.15
-
 IC50: 0.15 mM Rattus norvegicus honokiol
2.3.1.67 0.15
-
 IC50: 0.15 mM Rattus norvegicus magnolol
2.3.1.67 0.2
-
 IC50: 0.2 mM Rattus norvegicus chiyusaponin
2.3.1.67 0.29
-
 IC50: 0.29 mM Rattus norvegicus nordihydroguaiaretic acid