EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.57 | Berenil | competitive with respect to putrescine, i.e. diminazene aceturate | Ascaris suum | |
2.3.1.57 | Berenil | competitive with respect to putrescine, i.e. diminazene aceturate | Onchocerca volvulus | |
2.3.1.57 | Pentamidine | weak | Ascaris suum | |
2.3.1.57 | Pentamidine | weak | Onchocerca volvulus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.57 | 0.25 | - |
putrescine | - |
Ascaris suum | |
2.3.1.57 | 0.33 | - |
putrescine | - |
Onchocerca volvulus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.57 | additional information | Ascaris suum | enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations | ? | - |
? | |
2.3.1.57 | additional information | Onchocerca volvulus | enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.57 | Ascaris suum | - |
female adults | - |
2.3.1.57 | Onchocerca volvulus | - |
female adults | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.57 | partial | Ascaris suum |
2.3.1.57 | partial | Onchocerca volvulus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.57 | ovary | - |
Ascaris suum | - |
2.3.1.57 | uterus | - |
Ascaris suum | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.57 | 0.0006 | - |
- |
Onchocerca volvulus |
2.3.1.57 | 0.4 | - |
- |
Ascaris suum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.57 | acetyl-CoA + 1,5-diaminopentane | at 45% of the rate with putrescine | Onchocerca volvulus | CoA + N1-acetyl-1,5-diaminopentane | - |
? | |
2.3.1.57 | acetyl-CoA + 1,5-diaminopentane | at 39% of the rate with putrescine | Ascaris suum | CoA + N1-acetyl-1,5-diaminopentane | - |
? | |
2.3.1.57 | acetyl-CoA + 1,6-diaminohexane | at 74% of the rate with putrescine | Onchocerca volvulus | CoA + N1-acetyl-1,6-diaminohexane | - |
? | |
2.3.1.57 | acetyl-CoA + 1,6-diaminohexane | at 50% of the rate with putrescine | Ascaris suum | CoA + N1-acetyl-1,6-diaminohexane | - |
? | |
2.3.1.57 | acetyl-CoA + histamine | at about 30% of the rate with putrescine | Ascaris suum | CoA + N-acetylhistamine | - |
? | |
2.3.1.57 | acetyl-CoA + histamine | at about 30% of the rate with putrescine | Onchocerca volvulus | CoA + N-acetylhistamine | - |
? | |
2.3.1.57 | acetyl-CoA + putrescine | preference for putrescine | Ascaris suum | CoA + N-acetylputrescine | - |
? | |
2.3.1.57 | acetyl-CoA + putrescine | preference for putrescine | Onchocerca volvulus | CoA + N-acetylputrescine | - |
? | |
2.3.1.57 | acetyl-CoA + spermidine | very poor substrate, at 2-4% of the rate with putrescine | Ascaris suum | CoA + N1-acetylspermidine | - |
? | |
2.3.1.57 | acetyl-CoA + spermidine | very poor substrate, at 2-4% of the rate with putrescine | Onchocerca volvulus | CoA + N1-acetylspermidine | - |
? | |
2.3.1.57 | acetyl-CoA + spermine | very poor substrate, at 2-4% of the rate with putrescine | Ascaris suum | CoA + N1-acetylspermine | - |
? | |
2.3.1.57 | acetyl-CoA + spermine | very poor substrate, at 2-4% of the rate with putrescine | Onchocerca volvulus | CoA + N1-acetylspermine | - |
? | |
2.3.1.57 | additional information | not: histone | Ascaris suum | ? | - |
? | |
2.3.1.57 | additional information | not: histone | Onchocerca volvulus | ? | - |
? | |
2.3.1.57 | additional information | not: dopamine, serotonin | Ascaris suum | ? | - |
? | |
2.3.1.57 | additional information | not: dopamine, serotonin | Onchocerca volvulus | ? | - |
? | |
2.3.1.57 | additional information | enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations | Ascaris suum | ? | - |
? | |
2.3.1.57 | additional information | enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations | Onchocerca volvulus | ? | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.57 | 0.0012 | - |
Berenil | - |
Ascaris suum | |
2.3.1.57 | 0.0042 | - |
Berenil | - |
Onchocerca volvulus |