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Literature summary extracted from

  • Wood, N.P.; Jungermann, K.
    Inactivation of the pyruvate formate lyase of Clostridium butyricum (1972), FEBS Lett., 27, 49-52.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.54 Ferredoxin
-
 Escherichia coli
2.3.1.54 Ferredoxin
-
 Clostridium butyricum
2.3.1.54 S-adenosylmethionine
-
 Escherichia coli
2.3.1.54 S-adenosylmethionine
-
 Clostridium butyricum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.54 S-adenosyl-L-homocysteine
-
 Clostridium butyricum
2.3.1.54 S-adenosyl-L-homocysteine
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.54 pyruvate + CoA Clostridium butyricum required for synthesis of C1 units in anabolism acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA Escherichia coli catabolic function, leading to production of ATP acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA Enterococcus faecalis catabolic function, leading to production of ATP acetyl-CoA + formate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.54 Clostridium butyricum
-
 ATCC 19398
-
2.3.1.54 Enterococcus faecalis
-
 previously Streptococcus faecalis
-
2.3.1.54 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.54 pyruvate + CoA
-
 Escherichia coli acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA
-
 Enterococcus faecalis acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA
-
 Clostridium butyricum acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA required for synthesis of C1 units in anabolism Clostridium butyricum acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA catabolic function, leading to production of ATP Escherichia coli acetyl-CoA + formate
-
 ?
2.3.1.54 pyruvate + CoA catabolic function, leading to production of ATP Enterococcus faecalis acetyl-CoA + formate
-
 ?