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Literature summary extracted from

  • Mannens, G.; Siegers, G.; Claeys, A.
    Assay for acetyl-CoA:arylamine N-acetyltransferase by high-performance liquid chromatography applied to serotonin N-acetylation (1990), Biochim. Biophys. Acta, 1037, 1-6.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.5 dithiothreitol
-
 Columba sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.5 additional information
-
 additional information assay based on HPLC Columba sp.
2.3.1.5 0.24 0.25 tryptamine
-
 Columba sp.
2.3.1.5 0.25
-
 serotonin
-
 Columba sp.

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.5 Columba sp.
-
 pigeon
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.5 liver
-
 Columba sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.5 3.3
-
-
 Columba sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.5 acetyl-CoA + 4-nitroaniline
-
 Columba sp. CoA + N-acetyl-4-nitroaniline
-
 ?
2.3.1.5 acetyl-CoA + serotonin
-
 Columba sp. CoA + N-acetylserotonin
-
 ?
2.3.1.5 acetyl-CoA + tryptamine
-
 Columba sp. CoA + N-acetyltryptamine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.5 35
-
-
 Columba sp.

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.3.1.5 25 40 nearly maximal activity in this range Columba sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.5 9.5
-
 0.1 M glycine/KOH buffer Columba sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.5 9.3 9.5 about half-maximal activity at pH 9.3, maximal at 9.5 Columba sp.