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Literature summary extracted from

  • Schauer, R.
    Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase (1970), Hoppe-Seyler's Z. Physiol. Chem., 351, 749-758.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.45 cytosol
-
 Bos taurus 5829
-
2.3.1.45 microsome low activity Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.45 acetyl-CoA + sialic acid Bos taurus
-
 CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.45 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.45 submaxillary gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.45 acetyl-CoA + N-acetylneuraminate free acetylneuraminate Bos taurus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate few N-acetyl-O-acetylneuraminate bound to cytosolic glycoproteins, some bound to microsomes ?
2.3.1.45 acetyl-CoA + sialic acid
-
 Bos taurus CoA + N-acetyl-7-O(or 9-O-)-acetylneuraminate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.45 More in early days of investigation of sialate O-acetyltransferase it was not possible to discriminate clearly between 7- or 9-O-acetylated sialic acids enzymatically formed on a micro scale in order to denominate the enzyme correctly, there also exists the possibility of the existence of more than one O-acetyltransferases incorporating acetyl-groups into different positions of the sialic acid side chain, in contrast a hypothesis is presented for the requirement of only one transferase specific for the 7-OH group, after insertion of the O-acetyl group at O-7 the ester residue may migrate to O-9 afterwards a second O-acetyl group can be transferred by the same enzyme to O-7, which may migrate to O-8 and open the way for linking a third acetyl group to O-7 Bos taurus