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Literature summary extracted from

  • Chung, J.; Abano, D.A.; Fless, G.M.; Scanu, A.M.
    Isolation, properties, and mechanism of in vitro action of lecithin: cholesterol acyltransferase from human plasma (1979), J. Biol. Chem., 254, 7456-7464.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I required for transferase and phospholipase activity Homo sapiens
2.3.1.43 apolipoprotein A-I absolute requirement with phosphatidylcholine-cholesterol vesicles as a substrate Homo sapiens
2.3.1.43 additional information apo-A-II, apo-C-III and apo-D inhibit activation of enzyme by apo-A-1 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 apolipoprotein A-II
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.43 0.000091
-
 apolipoprotein-A-I
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.43 59000
-
 sedimentation equilibrium ultracentrifugation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.43 glycoprotein 24% carbohydrate by weight, 13 mol of mannose, 30 mol of galactose, 17 mol of glucosamine and 13 mol of sialic acid per mol of enzyme protein Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.43 affinity chromatography using an anti-apolipoprotein D immunoglobulin-Sepharose column Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
-
 Homo sapiens
2.3.1.43 0.01
-
 in cholesterol-lecithin vesicles activated with apolipoprotein A1, at 37°C and pH 7.1 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information phospholipase activity Homo sapiens ?
-
 ?
2.3.1.43 additional information lecithin-cholesterol single bilayer vesicles as substrate Homo sapiens ?
-
 ?
2.3.1.43 phosphatidylcholine + sterol
-
 Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 r