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Literature summary extracted from

  • De Vet, E.C.J.M.; Ijlst, L.; Oostheim, W.; Dekker, C.; Moser, H.W.; Van den Bosch, H.; Wanders, R.J.A.
    Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities (1999), J. Lipid Res., 40, 1998-2003.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.42 additional information deficient cell line caused by DNA 128 bp deletion leading to premature stop, strongly reduced activity Homo sapiens
2.3.1.42 additional information patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting, point mutation at nucleotide 848 leading to a premature stop Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.42 peroxisome
-
 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.42 additional information Homo sapiens patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting ?
-
 ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Homo sapiens peroxisomal enzyme involved in ether lipid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.42 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.42 fibroblast cell culture Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.42 0.000091
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Homo sapiens CoA + acyldihydroxyacetone phosphate
-
 ?
2.3.1.42 additional information patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting Homo sapiens ?
-
 ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate peroxisomal enzyme involved in ether lipid biosynthesis Homo sapiens CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.42 DHAPAT
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.42 5.4
-
 assay at Homo sapiens