BRENDA - Enzyme Database show

Transient state kinetic investigation of 5-aminolevulinate synthase reaction mechanism

Zhang, J.; Ferreira, G.C.; J. Biol. Chem. 277, 44660-44669 (2002)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Mus musculus
first step in heme biosynthesis pathway
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
Mus musculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.37
Mus musculus
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
2.3.1.37
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
three-step kinetic process, ordered kinetic mechanism, reaction mechanism
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486861
Mus musculus
5-aminolevulinate + CoA + CO2
-
486861
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
first step in heme biosynthesis pathway
486861
Mus musculus
5-aminolevulinate + CoA + CO2
-
486861
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486861
Mus musculus
5-aminolevulinate + CoA + CO2
-
486861
Mus musculus
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
required
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.3.1.37
pyridoxal 5'-phosphate
required
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.37
succinyl-CoA + glycine
Mus musculus
first step in heme biosynthesis pathway
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
Mus musculus
rate-limiting enzyme of heme biosynthesis
5-aminolevulinate + CoA + CO2
-
Mus musculus
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.37
succinyl-CoA + glycine
-
486861
Mus musculus
5-aminolevulinate + CoA + CO2
-
486861
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
first step in heme biosynthesis pathway
486861
Mus musculus
5-aminolevulinate + CoA + CO2
-
486861
Mus musculus
?
2.3.1.37
succinyl-CoA + glycine
rate-limiting enzyme of heme biosynthesis
486861
Mus musculus
5-aminolevulinate + CoA + CO2
-
486861
Mus musculus
?