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Literature summary extracted from

  • Zaidenzaig, Y.; Fitton, J.E.; Packman, L.C.; Shaw, W.V.
    Characterization and comparison of chloramphenicol acetyltransferase variants (1979), Eur. J. Biochem., 100, 609-618.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.28 2,2'-dithiobis(pyridine)
-
 Clostridium perfringens
2.3.1.28 2,2'-dithiobis(pyridine)
-
 Haemophilus influenzae
2.3.1.28 2,2'-dithiobis(pyridine)
-
 Proteus mirabilis
2.3.1.28 2,2'-dithiobis(pyridine)
-
 Streptococcus agalactiae
2.3.1.28 2,2'-dithiobis(pyridine)
-
 Streptomyces acrimycini

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.28 0.0093
-
 chloramphenicol
-
 Streptococcus agalactiae
2.3.1.28 0.01
-
 chloramphenicol
-
 Streptococcus pneumoniae
2.3.1.28 0.0166
-
 chloramphenicol
-
 Streptomyces acrimycini
2.3.1.28 0.0175
-
 chloramphenicol
-
 Haemophilus parainfluenzae
2.3.1.28 0.0205
-
 chloramphenicol
-
 Agrobacterium tumefaciens
2.3.1.28 0.0215
-
 chloramphenicol
-
 Clostridium perfringens
2.3.1.28 0.031
-
 chloramphenicol
-
 Proteus mirabilis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.28 22500
-
 x * 22500, SDS-PAGE Streptococcus pneumoniae
2.3.1.28 22500
-
 x * 22500, SDS-PAGE Proteus mirabilis
2.3.1.28 22500
-
 x * 22500, SDS-PAGE Staphylococcus sp.
2.3.1.28 22500
-
 x * 22500, SDS-PAGE Clostridium perfringens
2.3.1.28 22500
-
 x * 22500, SDS-PAGE Streptococcus agalactiae
2.3.1.28 22500
-
 x * 22500, SDS-PAGE Haemophilus parainfluenzae

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.28 Agrobacterium tumefaciens
-
-
-
2.3.1.28 Clostridium perfringens
-
-
-
2.3.1.28 Haemophilus influenzae
-
-
-
2.3.1.28 Haemophilus parainfluenzae
-
-
-
2.3.1.28 Proteus mirabilis
-
-
-
2.3.1.28 Staphylococcus sp.
-
 type A, type B and type C
-
2.3.1.28 Streptococcus agalactiae
-
-
-
2.3.1.28 Streptococcus pneumoniae
-
-
-
2.3.1.28 Streptomyces acrimycini
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Haemophilus influenzae CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Streptococcus pneumoniae CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Proteus mirabilis CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Staphylococcus sp. CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Agrobacterium tumefaciens CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Clostridium perfringens CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Streptococcus agalactiae CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Haemophilus parainfluenzae CoA + chloramphenicol 3-acetate
-
 ?
2.3.1.28 acetyl-CoA + chloramphenicol
-
 Streptomyces acrimycini CoA + chloramphenicol 3-acetate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.28 ?
-
 Haemophilus influenzae
2.3.1.28 ?
-
 Agrobacterium tumefaciens
2.3.1.28 ?
-
 Streptomyces acrimycini
2.3.1.28 ? x * 22500, SDS-PAGE Streptococcus pneumoniae
2.3.1.28 ? x * 22500, SDS-PAGE Proteus mirabilis
2.3.1.28 ? x * 22500, SDS-PAGE Staphylococcus sp.
2.3.1.28 ? x * 22500, SDS-PAGE Clostridium perfringens
2.3.1.28 ? x * 22500, SDS-PAGE Streptococcus agalactiae
2.3.1.28 ? x * 22500, SDS-PAGE Haemophilus parainfluenzae