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Literature summary extracted from

  • Kerkhoff, C.; Beuck, M.; Threige-Rasmussen, J.; Spener, F.; Knudsen, J.; Schmitz, G.
    Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes (1997), Biochim. Biophys. Acta, 1346, 163-172.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.26 liver fatty acid binding protein/bovine serum albumin small increase in activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 acyl-CoA binding protein 3fold decrease in activity Homo sapiens
2.3.1.26 acyl-CoA binding protein/oleoyl-CoA complexes strongly inhibit Homo sapiens
2.3.1.26 diazepam competes with oleoyl-CoA for its binding to microsomal membranes Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.26 0.025
-
 oleoyl-CoA bound to acyl-CoA binding protein Homo sapiens
2.3.1.26 0.03
-
 oleoyl-CoA in the absence of acyl-CoA binding protein Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 mononuclear phagocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 0.0000053 0.000008
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 additional information enzyme activity is regulated by the acyl-CoA binding protein ACBP Homo sapiens ?
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesteryl oleate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 assay at Homo sapiens