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Literature summary extracted from

  • Brecher, P.; Chan, C.T.
    Properties of acyl-CoA:cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits (1980), Biochim. Biophys. Acta, 617, 458-471.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.26 albumin
-
 Rattus norvegicus
2.3.1.26 albumin stimulates Oryctolagus cuniculus
2.3.1.26 cholesterol exogenous, not stimulatory Oryctolagus cuniculus
2.3.1.26 cholesterol exogenous, 25% increase of adrenal microsome activity and 2fold increase of activity in liver Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 bovine serum albumin inhibits at high concentrations Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome submicrosomal distribution Rattus norvegicus
-
-
2.3.1.26 microsome submicrosomal distribution Oryctolagus cuniculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Oryctolagus cuniculus
-
-
-
2.3.1.26 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 adrenal gland
-
 Rattus norvegicus
-
2.3.1.26 adrenal gland
-
 Oryctolagus cuniculus
-
2.3.1.26 aorta
-
 Rattus norvegicus
-
2.3.1.26 aorta atheroschlerotic tissue Oryctolagus cuniculus
-
2.3.1.26 liver
-
 Rattus norvegicus
-
2.3.1.26 liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 additional information
-
-
 Rattus norvegicus
2.3.1.26 additional information
-
 enhancement of activity following 8-11 weeks of cholesterol feeding Oryctolagus cuniculus
2.3.1.26 0.0001042
-
 aortic microsomal preparation Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol
-
 Oryctolagus cuniculus CoA + cholesterol ester
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Oryctolagus cuniculus CoA + cholesteryl oleate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 assay at Rattus norvegicus
2.3.1.26 37
-
 assay at Oryctolagus cuniculus