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Literature summary extracted from

  • Balasubramaniam, S.; Venkatesan, S.; Mitropoulos, K.A.; Peters, T.J.
    The submicrosomal localization of acyl-coenzyme A-cholesterol acyltransferase and its substrate, and of cholesteryl esters in rat liver (1978), Biochem. J., 174, 863-872.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 Digitonin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome submicrosomal distribution Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Rattus norvegicus
-
 male Wistar strain
-
2.3.1.26 Rattus norvegicus male Wistar
-
 male Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 0.00006
-
 cholesterol added in Tween 80 Rattus norvegicus
2.3.1.26 0.000063
-
 cholesterol added in acetone Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol
-
 Rattus norvegicus male Wistar CoA + cholesterol ester
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Rattus norvegicus male Wistar CoA + cholesteryl oleate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.26 CoA required by the in-situ acyl-CoA production Rattus norvegicus