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Literature summary extracted from

  • Sanjanwala, M.; Sun, G.Y.; MacQuarrie, R.
    Purification and kinetic properties of lysophosphatidylinositol acyltransferase from bovine heart muscle microsomes and comparison with lysophosphatidylcholine acyltransferase (1989), Arch. Biochem. Biophys., 271, 407-413.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.23 Chloroquine activation Bos taurus
2.3.1.23 iodoacetate activation Bos taurus
2.3.1.23 thimerosal i.e. sodium ethylmercurithiosalicylate, activation Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.23 ADP
-
 Bos taurus
2.3.1.23 AMP
-
 Bos taurus
2.3.1.23 Dibucaine
-
 Bos taurus
2.3.1.23 additional information not inhibited by ATP Bos taurus
2.3.1.23 procaine
-
 Bos taurus
2.3.1.23 Tetracaine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.23 microsome
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.23 Cibacron blue agarose, DEAE cellulose, Matrex green A, 1-acylglycerophosphoinositol O-acyltransferase Bos taurus
2.3.1.23 solubilized with CHAPS Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 heart
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.23 4.125
-
 1-acylglycerophosphoinositol O-acyltransferase Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
 Bos taurus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
 r
2.3.1.23 arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphoinositol preferred acyl donor arachidonoyl-CoA, other acyl donors: cis,cis-11,14-eicosadienoyl-CoA, cis-11-eicosaenoyl-CoA, linolenoyl-coA, linoleoyl-CoA, oleoyl-CoA, stearoyl-CoA, palmitoleoyl-CoA, palmitoyl-CoA, dodecanoyl-CoA and decanoyl-coA, no activity with 1-acyl-sn-glycero-3-phosphocholine Bos taurus CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.23 37
-
-
 Bos taurus